Drug-resistant bug behind Pakistan's deadly typhoid outbreak

Drug-resistant bug behind Pakistan’s deadly typhoid outbreak


In February, scientists reported a major outbreak of typhoid fever in Sindh, Pakistan caused by an extensively drug-resistant superbug strain. Research by Britain’s Wellcome Sanger Institute found that the typhoid strain had mutated and acquired an extra piece of DNA (from another microbe, likely E.coli) that rendered it resistant to multiple antibiotics.
The typhoid outbreak began in the city of Hyderabad, Pakistan in November 2016 and has since spread and local health authorities detected more than 800 cases of drug-resistant typhoid in Hyderabad alone in a ten-month period between 2016 and 2017.
The typhoid strain causing the outbreak is now resistant to five antibiotics, more than seen in any outbreak before. This is the world’s first outbreak of ‘extensively drug-resistant (or XDR) typhoid.
This new superbug typhoid strain is resistant to three first-line antibiotics i.e. chloramphenicol, ampicillin and trimethoprim-sulfamethoxazole, as well as fluoroquinolones and third generation cephalosporins.
The results of this study were published in Jan/Feb 2018 in the scientific journal mBio. For details of the study please click the link given here: http://mbio.asm.org/content/9/1/e00105-18.full.pdf
– Third World Network


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