More than 13 million people in the central United States were under tornadowatches, the National Weather Service (NWS) said.
A "very dangerous half-mile-wide tornado" touched down in Ohio state, NWSsaid.
One struck the rural town of Indian Lakes in western Ohio.
"It's pure devastation. I have never seen anything like this in my entirelife," Amber Fagan, president of the Indian Lakes Chamber of Commerce, told aColumbus ABC television station.
"Downtown, it's bad. It's very bad."
Three people died in a mobile home park in Winchester, Indiana, when asuspected tornado struck, the ABC and NBC television networks reported,citing state police.
Storms hopscotched across the Ohio Valley, spawning apparent tornadoes in anumber of areas.
Kentucky Governor Andy Beshear said on social media that a tornado movedthrough Gallatin and Trimble in his state but left no fatalities.
Tornadoes, a weather phenomenon that is as impressive as it is difficult topredict, are relatively common in the United States, especially in thecentral and southern parts of the country, reports BSS.